dav, do not listen to Bal, he is always doom and gloom, the instos will always front up for any C R always have and always will as the upside for Biotechs is 10 fold when and if it comes, they know how the game is played in the U S it can be 10 - 20 years for all of the approvals to be granted , they recgonise, realise and WHEN they go bingo, who would want to miss out on a 10-20 bagger after holding for 10 years !!